The paper uses EEG and machine learning to analyze how functional brain networks reorganize after ayahuasca, finding decreased hub influence and increased distributed pathways in the right hemisphere.

bioRxiv · Dec 11, 2025 · PreprintNeuroscience

Ayahuasca Shifts Brain Dynamics Toward Higher Entropy: Persistent Elevation of Ising Temperature Correlates with Acute Subjective Effects

Rodrigo M. Cabral-Carvalho, Fernanda Palhano-Fontes, Dráulio Barros de Araújo, João Ricardo Sato

This study uses fMRI and the Ising model to show ayahuasca increases brain entropy, with subacute effects correlating with acute subjective experiences.

bioRxiv · Apr 25, 2025 · PreprintNeuroscience

Mapping Pharmacologically-induced Functional Reorganisation onto the Brain's Neurotransmitter Landscape

Andrea I. Luppi, Justine Y. Hansen, R. Adapa, Robin Lester Carhart-Harris, Leor Roseman, Christopher Timmermann, Daniel Golkowski, Andreas Ranft, Rüdiger Ilg, Denis Jordan, Vincent Luce Bonhomme, Audrey Vanhaudenhuyse, Athena Demertzi A, Océane Jaquet, Mohamed Ali Bahri, , Emmanuel Andreas Stamatakis

This study maps how pharmacological drugs alter brain function by linking neurotransmitter receptor distribution with drug-induced changes in functional MRI connectivity.

bioRxiv · Jul 12, 2022 · PreprintNeuroscience

d-Lysergic acid diethylamide has major potential as a cognitive enhancer

Felipe Augusto Cini da Silva, Isis Moraes Ornelas, Encarni Marcos, Livia Goto‐Silva, Juliana Minardi Nascimento, Sérgio Ruschi, José Alexandre Salerno, Karina Karmirian, Marcelo Costa, Eduardo Bouth Sequerra, Dráulio Barros de Araújo, Luís Fernando Tófoli, César Rennó‐Costa, Daniel Martins‐de‐Souza, Amanda Feilding, , Sidarta Tollendal Gomes Ribeiro

This study shows that d-LSD enhances novel object preference in young and adult rats and can rescue this effect in old rats when combined with enriched environment exposure.

bioRxiv · Dec 6, 2019 · PreprintNeuroscience

Acute antidepressant effect of ayahuasca in juvenile non-human primate model of depression.

Flávia Santos da Silva, Erick Allan dos Santos Silva, Geovan Menezes de Sousa, João Paulo Maia‐de‐Oliveira, Vanessa de Paula Soares-Rachetti, Dráulio Barros de Araújo, Maria Bernardete Cordeiro de Sousa, Bruno Lobão Soares, Nicole Leite Galvão Coelho

This study evaluates the antidepressant effects of ayahuasca in a juvenile non-human primate model of depression, showing faster and more durable recovery compared to nortriptyline.

bioRxiv · Jan 25, 2018 · PreprintNeuroscience

Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryptamine

Vanja Dakic, Juliana Minardi Nascimento, Rafaela Sartore, Renata de Moraes Maciel, Dráulio Barros de Araújo, Sidarta Tollendal Gomes Ribeiro, Daniel Martins‐de‐Souza, Stevens Kastrup Rehen

This study investigates proteomic changes in human cerebral organoids treated with 5-MeO-DMT, identifying 934 differentially expressed proteins and suggesting anti-inflammatory and synaptic modulation effects.

Scientific Reports · Oct 4, 2017Peer-reviewedNeuroscience