Rafaela Sartore

Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo

The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.

Cell-type specific developmental defects in PTEN-mutant cortical organoids converge on abnormal circuit activity

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.

Short term changes in the proteome of human cerebral organoids induced by 5-methoxy-N,N-dimethyltryptamine

This study investigates proteomic changes in human cerebral organoids treated with 5-MeO-DMT, identifying 934 differentially expressed proteins and suggesting anti-inflammatory and synaptic modulation effects.