Mingyu Liang

A single-cell map of hypertension

This study maps the molecular landscape of hypertension using single-cell data from multiple organs and models, linking genetic variants to disease mechanisms.

Per- and Polyfluoroalkyl Substances Induces Salt-Sensitive Hypertension by Upregulating Epithelial Sodium Channel - The First Experimental Evidence Supporting Causality

This paper shows that PFAS exposure causes salt-sensitive hypertension and kidney injury in mice by increasing ENaC activity in the kidney.

Chromatin interaction maps of human arterioles reveal new mechanisms for the genetic regulation of blood pressure

The paper maps chromatin interactions in human arterioles, linking genetic variants to gene expression and hypertension mechanisms.

Physiological role and mechanisms of action for a long noncoding haplotype region

The paper investigates the physiological role and mechanisms of a noncoding haplotype associated with blood pressure by combining animal models, genome editing, and chromatin analysis.

Global and genetic regulation of gene expression in human endothelial and vascular smooth muscle cells

The paper maps epigenetic and genetic regulation in human endothelial and vascular smooth muscle cells, showing strong correlations between gene expression and chromatin features, and demonstrates SNP effects on gene expression through chromatin loops.

Insufficient fumarase contributes to generating reactive oxygen species in Dahl salt sensitive rats

This study shows fumarase insufficiency in Dahl SS rats increases reactive oxygen species by altering ROS production sites and antioxidant defenses.