Xiaowen Bai

Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity

This study uses 3D human cerebral organoids and pediatric serum to identify molecular signatures of anesthetic-induced neurotoxicity, revealing shared dysregulated RNAs linked to neuronal injury and neurodevelopmental disruption.

SNRK regulates TGFbeta levels in atria to control cardiac fibrosis

This study shows that SNRK in atrial cardiomyocytes reduces TGFbeta1 levels, preventing fibrosis and heart failure.

Global and genetic regulation of gene expression in human endothelial and vascular smooth muscle cells

The paper maps epigenetic and genetic regulation in human endothelial and vascular smooth muscle cells, showing strong correlations between gene expression and chromatin features, and demonstrates SNP effects on gene expression through chromatin loops.