Author

James Alexander Pearson

Cardiff UniversityORCID 0000-0002-2867-2269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gavin A. BewickiD· 2 shared Joanne E. DaviesiD· 2 shared Naila HaqiD· 2 shared Shanta Jean PersaudiD· 2 shared Alejandro Huerta UribeiD· 1 shared Alexandra Howell· 1 shared Alexandra L. Howell· 1 shared Andrew E. HoganiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

Gavin A. BewickORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Neuropeptide Y4 receptor activation delays autoimmune diabetes by reprogramming β-cell stress and immune tolerance

Naila Haq, Klaudia Toczyska, Anowara Islam, Oladapo Edward Olaniru, Yuxian Lei, Ming Hu, M Zhao, R Müller, Mohammed Kamran Afzal Mirza, Nick Fine, David J. Hodson, Shanta Jean Persaud, Annette Gabriele Beck‐Sickinger, James Alexander Pearson, Gavin A. Bewick

This study shows that activating the Y4R receptor protects β-cells and modulates islet immunity, delaying autoimmune diabetes in multiple models.

bioRxiv · Jul 4, 2026 · PreprintCell Biology

Tracking GAD-specific T-cell expansions in Type 1 diabetes by intradermal GAD-Alum challenge

Stephanie Jean Hanna, Emma Robinson, Terri C. Thayer, Maki Nakayama, Laurie G. Landry, Robert Andrews, Garry M. Dolton, Joanne E. Davies, Evangelia Williams, James Alexander Pearson, Andrew Kelvin Sewell, Parth Narendran, David Cameron Wraith, Alexandra Howell, Philippa Young, , Danijela Tatović

This paper uses intradermal GAD-Alum challenge and scRNA-seq to identify and profile GAD-reactive T cells in type 1 diabetes.

JCI Insight · May 22, 2026Peer-reviewedImmunology

ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity

Benjamin Jenkins, Yasmin R Jenkins, Fernando M. Ponce-Garcia, Chloe Moscrop, Iain A. Perry, Matthew D. Hitchings, Alejandro Huerta Uribe, Federico Bernuzzi, Simon Eastham, J. Cronin, Ardena Berisha, Alexandra L. Howell, Joanne E. Davies, Julianna Blagih, Douglas James Veale, , Nicholas Jones

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

bioRxiv · Mar 19, 2025 · PreprintImmunology

NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice

Daniel Egbase, Sophie R. Sayers, Naila Haq, Jithu James Varghese, Vesela Gesheva, Sreya Bhattacharya, Jay Kynaston, Ella-Louise Hubber, Lorna I. F. Smith, Timothy J. Pullen, Henry Gerdes, Vivian K. Lee, David Hopkins, Min Zhao, Yee Cheah, , Paul Caton

This study shows that inhibiting NAMPT reduces inflammation and beta-cell damage in T1D by blocking cytokine-mediated immune responses in mice.

bioRxiv · Jan 14, 2025 · PreprintCell Biology