Shelley S. Tworoger

Functional Data Analysis of Spatial Clustering Identifies Prognostic T Cell Patterns in Ovarian Cancer

The paper develops a functional data analysis framework to model spatial clustering in ovarian cancer, identifying prognostic T cell patterns beyond immune cell abundance.

Myeloid cell networks determine reinstatement of original immune environments in recurrent ovarian cancer

The paper identifies immune phenotypes and myeloid cell networks in recurrent ovarian cancer that influence prognosis and immune environment reinstatement.

Patterns of extreme outlier RNA expression in population data reveal sporadic over-activation of genes with co-regulated modules in subsets of individuals

The paper identifies sporadic over-activation of co-regulated genes with extreme outlier RNA expression in multiple species and tissues, showing these patterns are not inherited but may reflect gene regulatory network dynamics.

Quantifiable Blood TCR Repertoire Components Associated with Immune Aging

The paper identifies age-associated TCR repertoire components using a new computational framework and links them to immune aging and clinical outcomes.