Discoidins are cytosolic lectins that recognize methylated L-rhamnose epitopes on mycobacterial glycolipids and glycopeptidolipids upon vacuole damage
Davide D’Amico, Gregory Goudge, Mélanie Foulon…·Thierry Soldati
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University of GenevaORCID 0000-0002-6988-1112Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Davide D’Amico, Gregory Goudge, Mélanie Foulon…·Thierry Soldati
Céline Michard, Angélique Perret, Mélanie Foulon…·Thierry Soldati
This study shows that EsxA initiates MCV membrane damage while PDIM amplifies lesions to cause catastrophic rupture, enabling bacterial escape.
Mélanie Foulon, Sylvana V. Hüttel, Leonhard F. Breitsprecher…·Caroline Barisch
The paper shows that lipid metabolism in mycobacteria is linked to their subcellular location, with FACL6 deletion disrupting lipid handling and reducing intracellular fitness.
Davide D’Amico, Lyudmil Raykov, Thierry Soldati, Mélanie Foulon
This study shows mycobacteria shed surface components during early infection, which affect both infected and bystander host cells.