Cell volume tunes macrophage innate inflammatory responses through promoting type I interferon signalling.
James R. Cook, Tara A. Gleeson, Sara Gago, Stuart McRae Allan, Kevin N. Couper, Catherine B. Lawrence, David Brough, J. P. Green
This study shows that cell volume changes in macrophages enhance type I interferon signaling and inflammation through a DNA- and STING-dependent mechanism.
The Journal of Cell Biology · Mar 13, 2026Peer-reviewedImmunology