This paper identifies the LIF-LIFR axis as a key regulator of liver regeneration through LSECs, promoting angiogenesis and HGF release, and suggests therapeutic strategies for liver repair.

bioRxiv · Feb 25, 2026 · PreprintCell Biology

Vascular tortuosity quantification as an outcome metric of the oxygen-induced retinopathy model of ischemic retinopathy

Kyle V. Marra, Jimmy Chen, Hailey Kay Robles-Holmes, Joseph Michael Miller, Guoqin Wei, Edith Aguilar, Yoichiro Ideguchi, Kristine B. Ly, Sofia Prenner, Deniz Erdogmus B, Napoleone Ferrara, J. Peter Campbell, Martin Friedlander, Eric Nudleman

This study quantifies vascular tortuosity in the OIR model, showing it correlates with disease activity and responds to treatment with aflibercept.

bioRxiv · Oct 2, 2022 · PreprintNeuroscience

Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells

Sergii Domanskyi, Alex Hakansson, Michelle Y. Meng, Benjamin K. Pham, Joshua Graff Zivin, Carlo Piermarocchi, Giovanni Paternostro, Napoleone Ferrara

The paper identifies naturally occurring receptor combinations in endothelial cells using single-cell data and introduces a software tool to analyze them, showing evolutionary conservation and relevance to angiogenesis.

Scientific Reports · Apr 6, 2022Peer-reviewedSystems Biology