Author

David R. Owen

Imperial College LondonORCID 0000-0002-1198-7563Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:differential expression· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 4 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2

Frequent Co-Authors

Amy M. SmithiD· 5 shared Paul McMahan MatthewsiD· 5 shared Nurun Nahar FancyiD· 4 shared Stergios TsartsalisiD· 4 shared Robert C. J. Muirhead· 3 shared Aisling McGarryiD· 2 shared Aurélien M. BadinaiD· 2 shared Benjamin B. TournieriD· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersNeuroscience

Amy M. SmithORCID

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Author profile →

7 papers

Recent·Most cited

ProCyon: A multimodal foundation model for protein phenotypes

Owen Queen, Yepeng Huang, Robert Calef, Valentina Giunchiglia, Tianlong Chen, George Dasoulas, LeAnn Tai, Gianmarco Abbadessa, Owain Howell, Michelle M. Li, Yasha Ektefaie, Ayush Noori, Ildiko Farkas, Joseph S. Brown, Tom Cobley, , Marinka Žitnik

This paper introduces a multimodal foundation model for predicting protein phenotypes using sequence, structure, and natural language, showing competitive performance and novel insights into disease-related proteins.

bioRxiv · Dec 10, 2024 · PreprintBioinformatics

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer's disease

Stergios Tsartsalis, Hannah Sleven, Nurun Nahar Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal Rokicki, Vicky M. N. Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, , Paul McMahan Matthews

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

Nature Communications · Mar 12, 2024Peer-reviewedNeuroscience

Altered astrocytic and microglial homeostasis characterizes a decreased proinflammatory state in bipolar disorder

Quentin Amossé, Benjamin B. Tournier, Aurélien M. Badina, Lilou Marchand-Maillet, Laurene Abjean, Sylvain Lengacher, Nurun Nahar Fancy, Amy M. Smith, Yeung-Yeung Leung, Verena Santer, Valentina Garibotto, David R. Owen, Camille Piguet, Kelly Ceyzériat, Stergios Tsartsalis, P. Millet

This study identifies cell type-specific immune alterations in bipolar disorder brains, showing reduced proinflammatory microglia and metabolic/immune dysregulation in astrocytes.

bioRxiv · Oct 29, 2023 · PreprintNeuroscience

Etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cells

Jordan M. Osmond, John Bradley Williams, Paul McMahan Matthews, David R. Owen, Craig Stephen Moore

This paper shows etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cells, with anti-inflammatory effects independent of its known TSPO and GABAA receptor interactions.

bioRxiv · Sep 19, 2023 · PreprintNeuroscience

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

Erik Nutma, Nurun Nahar Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene N. Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper J. Anink, David Story, Siddharthan Chandran, Jiabin Tang, , David R. Owen

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

Nature Communications · Aug 28, 2023Peer-reviewedNeuroscience

Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology

Amy M. Smith, Karen Davey, Stergios Tsartsalis, Combiz Khozoie, Nurun Nahar Fancy, See Swee Tang, Eirini Liaptsi, Maria Weinert, Aisling McGarry, Robert C. J. Muirhead, Steve Gentleman, David R. Owen, Paul McMahan Matthews

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.

Acta Neuropathologica · Nov 12, 2021Peer-reviewedNeuroscience

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy Body diseases

Rahel Feleke, Regina Hertfelder Reynolds, Amy M. Smith, Bension Shlomo Tilley, Sarah A. Gagliano Taliun, John Hardy, Paul McMahan Matthews, Steve Gentleman, David R. Owen, Michael R. Johnson, Prashant Kumar Srivastava, Mina Ryten

This study uses transcriptomic profiling to identify common and distinct molecular features across Lewy Body diseases, highlighting RNA splicing dysregulation and potential therapeutic targets.

Acta Neuropathologica · Jul 26, 2021Peer-reviewedNeuroscience