Nurun Nahar Fancy

The paper examines how proximity to tangle-bearing neurons affects transcriptional states in human entorhinal cortex cells, finding that nearby neurons and glia show distinct molecular signatures related to disease.

The paper identifies intrinsic molecular features of calbindin-expressing neurons in the entorhinal cortex that contribute to their vulnerability in Alzheimer's disease and suggests potential therapeutic targets.

This study examines the effect of the ABCA7 rs3752231 variant on glial responses to amyloid-β and plaque maturation in Alzheimer's disease using post-mortem brain data and single-nucleus RNA sequencing.

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

This study identifies cell type-specific immune alterations in bipolar disorder brains, showing reduced proinflammatory microglia and metabolic/immune dysregulation in astrocytes.

Omix integrates and analyzes multi-omics data to generate pseudo-temporal profiles in Alzheimer's Disease using bulk proteomics and transcriptomics datasets.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper reanalyzes an Alzheimer's disease snRNA-Seq dataset using improved methods, finding 549 times fewer differentially expressed genes at an FDR of 0.05.

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.

scFlow provides a scalable, reproducible pipeline for analyzing single-cell RNA-seq data, demonstrating its utility with public datasets and extensibility as an open-source tool.