Maria Weinert

The paper presents a method to isolate rare cell populations from human post-mortem brain with high purity, demonstrating 100% microglial purity using fluorescence-activated nuclear sorting.

MotifPeeker benchmarks epigenomic profiling methods using motif enrichment as a metric, providing an HTML report with minimal input.

The paper optimizes TIP-seq peak calling parameters to improve peak precision and alignment with known motifs.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

This study uses single-nuclei RNA sequencing to analyze astrocyte and microglial transcriptomes in Alzheimer's disease brains, identifying gene expression differences linked to amyloid-beta and phospho-tau pathology.