Wenfan Ke

The paper investigates how shared Su(Hw) binding sites between TAD boundaries affect long-distance regulation and physical interactions in Drosophila.

The paper introduces Domino, a deep learning framework that models sequence-to-function relationships to uncover the context-specific grammar of Drosophila chromatin insulation.

The paper identifies distal and interchromosomal chromatin interactions in T cells using a new algorithm and links them to gene regulation through epigenomic analysis.

The paper investigates how marsupial neonates use cathelicidin antimicrobial peptides for immune protection through genomic clustering and enhancer sharing, showing their effectiveness in a sepsis model.

The paper investigates the homie insulator in Drosophila to understand its substructure and functional properties, revealing that specific sub-elements contribute to different insulating and long-range pairing activities.

This study tests two models for TAD boundary formation in flies and finds that boundary pairing, not loop extrusion, determines TAD endpoints.

The paper investigates how loop topology in Drosophila TADs affects physical and regulatory landscapes by replacing boundaries and analyzing the resulting structural and functional changes.