Metadomain and metaloop genome interactions in mammalian T cells

Gabriel A. Dolsten; Zhong-Min Wang; Xiao Jun Huang; Susie Song; Michael J. Wilson; Xinyang Bing; Wenfan Ke; Thomas R. Cafiero; Amy N. Nelson; Sebastian Fernando; Alexander Ploß; Paul D. Schedl; Michael Levine; Aaron D. Viny; Alexander Yu Rudensky; Yuri Pritykin

doi:10.1016/j.celrep.2026.117341

GenomicsCell ReportsMay 1, 2026

Peer-reviewed journal article

Metadomain and metaloop genome interactions in mammalian T cells

Gabriel A. Dolsten, Zhong-Min Wang iD, Xiao Jun Huang iD, Susie Song, Michael J. Wilson, Xinyang Bing iD, Wenfan Ke iD, Thomas R. Cafiero iD, Amy N. Nelson iD, Sebastian Fernando iD, Alexander Ploß iD, Paul D. Schedl iD, Michael Levine iD, Aaron D. Viny iD, Alexander Yu Rudensky iD, Yuri Pritykin iD

Abstract

Recent studies have advanced our understanding of chromosomal organization and its principal role in gene regulation. However, most analyses have focused on short-range interactions (2 Mb) chromatin interactions linked to gene regulation in T cells - A new algorithm identifies distal and interchromosomal meta-TADs and metaloops - An interchromosomal T cell-specific active hub emerges from metadomain clustering - Epigenomic compendium implicates TFs associated with long-range interactions

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