Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles
You Jin Song, Min Kyung Shinn, Sushant Bangru, Yu Wang, Qinyu Sun, Qinyu Hao, Pankaj Chaturvedi, Susan M. Freier, Pablo Pérez‐Piñera, Erik Russell Nelson, Andrew S. Belmont, Mitchell Guttman, Supriya G. Prasanth, Auinash Kalsotra, Rohit V. Pappu, Kannanganattu V. Prasanth
The paper shows that MALAT1 long noncoding RNA forms condensates with splicing factors to regulate hypoxia-induced alternative splicing near nuclear speckles.
Molecular Cell · Mar 1, 2026Peer-reviewedMolecular Biology