This study uses MINFLUX nanoscopy to directly visualize MCM helicase activation and replisome coupling in human cells, showing sister replisomes remain coupled at ~40 nm during S phase.

bioRxiv · Aug 24, 2026 · PreprintCell Biology

Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles

You Jin Song, Min Kyung Shinn, Sushant Bangru, Yu Wang, Qinyu Sun, Qinyu Hao, Pankaj Chaturvedi, Susan M. Freier, Pablo Pérez‐Piñera, Erik Russell Nelson, Andrew S. Belmont, Mitchell Guttman, Supriya G. Prasanth, Auinash Kalsotra, Rohit V. Pappu, Kannanganattu V. Prasanth

The paper shows that MALAT1 long noncoding RNA forms condensates with splicing factors to regulate hypoxia-induced alternative splicing near nuclear speckles.

Molecular Cell · Mar 1, 2026Peer-reviewedMolecular Biology

Orc6 at replication fork enables efficient mismatch repair

Yo-Chuen Lin, Arindam Chakraborty, Dazhen Liu, Jaba Mitra, Lyudmila Y. Kadyrova, Rosaline Y.C. Hsu, Mariam K. Arif, Sneha Adusumilli, Taekjip Ha, Farid A. Kadyrov, Kannanganattu V. Prasanth, Supriya G. Prasanth

This paper identifies hOrc6's role in promoting S-phase progression by facilitating mismatch repair complex assembly and activity at the replication fork.

bioRxiv · May 10, 2021 · PreprintMolecular Biology