Caroline Trumpff

The paper investigates how mitochondrial energy capacity affects brain function during cognitive, sensory, and affective tasks, finding that working memory is more vulnerable to energetic stress than sensory or affective processes.

The paper profiles mitochondrial phenotypes in immune cells of mitochondrial disease patients and finds they are largely preserved and not strongly linked to disease severity.

This study examines salivary GDF15 levels and their associations with biopsychosocial factors and stress reactivity in healthy adults.

The paper introduces a framework to quantify mitochondrial specialization and plasticity using transcriptomic data across various contexts.

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.

The paper develops three computational pipelines to analyze longitudinal saliva proteomics data and identifies significant differences in proteome dynamics between healthy controls and mitochondrial disease patients.

The paper examines cf-mtDNA and GDF15 as potential biomarkers of mitochondrial health in aging, finding GDF15 correlates with age and diabetes while cf-mtDNA does not.

This study examines associations between mitochondrial markers, maternal distress, and pregnancy outcomes in two cohorts, finding correlations between GDF15 levels and gestational age and BMI.

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

MitoQuicLy quantifies cf-mtDNA in plasma, serum, and saliva with high agreement to column-based methods, showing significant inter-individual and biofluid-specific differences.

This study measures dynamic changes in cell-free mitochondrial DNA in human saliva and finds it varies significantly over time, correlates with cortisol awakening response, and inversely with interleukin 6.

This study shows psychological stress increases circulating cell-free mitochondrial DNA (ccf-mtDNA) in humans through glucocorticoid signaling, with no change in nuclear DNA levels.