Martin A. Picard

This study quantifies the energetic cost of norepinephrine signaling in primary human fibroblasts, revealing dynamic changes in glycolysis and oxidative phosphorylation over time.

This paper introduces a neuroimaging framework to map brain mitochondria non-invasively and finds age-related declines in mitochondrial density and respiratory capacity, along with disease-specific alterations and links to systemic stress and cognition.

The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.

The paper investigates how mitochondrial energy capacity affects brain function during cognitive, sensory, and affective tasks, finding that working memory is more vulnerable to energetic stress than sensory or affective processes.

The paper profiles mitochondrial phenotypes in immune cells of mitochondrial disease patients and finds they are largely preserved and not strongly linked to disease severity.

This study shows that electroconvulsive therapy (ECT) improves motor function in Parkinsonian mice by promoting dopaminergic axon regeneration and restoring striatal circuitry.

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

The paper uses electron microscopy to analyze mitochondrial DNA-containing extracellular vesicles in human biofluids, showing that cf-mtDNA is often associated with double-membrane particles.

The paper examines mitochondrial distribution patterns across tissues and finds they lack coherence, suggesting tissue-specific and individualized regulatory mechanisms.

The paper creates a brain-wide map of mitochondrial phenotypes by combining physical voxelization with biochemical profiling, revealing regional differences in mitochondrial density and function.

This study examines salivary GDF15 levels and their associations with biopsychosocial factors and stress reactivity in healthy adults.

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.

The paper develops three computational pipelines to analyze longitudinal saliva proteomics data and identifies significant differences in proteome dynamics between healthy controls and mitochondrial disease patients.

The paper examines cf-mtDNA and GDF15 as potential biomarkers of mitochondrial health in aging, finding GDF15 correlates with age and diabetes while cf-mtDNA does not.

This study examines associations between mitochondrial markers, maternal distress, and pregnancy outcomes in two cohorts, finding correlations between GDF15 levels and gestational age and BMI.

The paper quantifies somatic mitochondrial DNA insertions (Numts) in human brain and fibroblasts, showing their accumulation over time and association with lifespan.

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

MitoQuicLy quantifies cf-mtDNA in plasma, serum, and saliva with high agreement to column-based methods, showing significant inter-individual and biofluid-specific differences.

This study finds that blood mitochondrial DNA copy number is consistently associated with personality traits and mediates the link between personality and mortality in two genetic cohorts.

This study measures dynamic changes in cell-free mitochondrial DNA in human saliva and finds it varies significantly over time, correlates with cortisol awakening response, and inversely with interleukin 6.

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

This study maps mitochondrial morphology in different neuronal compartments of the aging mouse hippocampus using 3D electron microscopy, revealing age-related differences in mitochondrial structure across cell types.

The paper examines mitochondrial respiratory chain capacity and its association with stress-related behaviors in mice, identifying brain networks linked to anxiety-like behavior.

This study shows psychological stress increases circulating cell-free mitochondrial DNA (ccf-mtDNA) in humans through glucocorticoid signaling, with no change in nuclear DNA levels.