Gilles Gouspillou

This study finds that serum C-terminal agrin fragment (CAF) increases with age and is linked to neuromuscular decline and reduced physical function, with physical activity mitigating these effects in older men.

This study shows that Parkin overexpression reduces muscle atrophy and improves mitochondrial bioenergetics but does not improve key histological features in a DMD mouse model.

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

This study measures dynamic changes in cell-free mitochondrial DNA in human saliva and finds it varies significantly over time, correlates with cortisol awakening response, and inversely with interleukin 6.