NLRP3 acts as a direct sensor of intracellular potassium ions
Ana Tapia‐Abellán, L.-M. Funk, Tobias Schäfer, Jelena Grga, Jane Torp, Corinna Gehring-Khav, Inga V. Hochheiser, Caroline Schönfeld, Maria Mateo Tortola, Fehime Kara Eroğlu, Gaopeng Li, Helmut Bischof, Robert Łukowski, Jasmin Beate Kuemmerle-Deschner, Liudmila Andreeva, , Alexander N.R. Weber
This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.
bioRxiv · Mar 12, 2026 · PreprintImmunology