Author
Universitätsklinikum TübingenORCID 0000-0002-6365-6598Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Ana Tapia‐Abellán, L.-M. Funk, Tobias Schäfer…·Alexander N.R. Weber
This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.
Kevin Wilhelmsen, Aditi Deshpande, Sarah U. Tronnes…·Rebecca C. Coll
This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.
Aude Sylvain, Natacha Stoehr, Fupeng Ma…·Zuni I. Bassi
This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.