Jane Torp

This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

This paper identifies and characterizes BAL-1516, a CNS-penetrating NLRP3 inhibitor that blocks inflammasome formation and shows potential for treating neuroinflammatory diseases.

ArtSeg uses a deep learning model to automatically segment and remove artifacts from brightfield microscopy images using image-level labels, improving downstream analysis without requiring pixel-level annotations.