Single-cell transcriptomics reveal individual and synergistic effects of Trisomy 21 and GATA1s on hematopoiesis
Kaoru Takasaki, Eric K. Wafula, Sara S. Kumar, David L Smith, Ying Ting Sit, Alyssa L. Gagne, Deborah L. French, Christopher S. Thom, Stella T. Chou
This study uses single-cell RNA-sequencing to analyze the individual and combined effects of Trisomy 21 and GATA1s on hematopoietic progenitor cells, revealing their impact on lineage skew and proliferation.
bioRxiv · May 24, 2024 · PreprintMolecular Biology