Chan-Shuo Wu

A Network Medicine Approach to Investigating ME/CFS Pathogenesis in Severely Ill Patients: A Pilot Study

This pilot study uses network medicine on whole genome sequencing data to identify ME/CFS-associated proteins and pathways, suggesting a neuroimmune disorder with links to estrogen signaling and other conditions.

RNA LEVER Mediates Long-Range Regulation of ε-globin by Keeping PRC2 in Check

The paper identifies LEVER RNA as a regulator of ε-globin expression by inhibiting PRC2-mediated H3K27 methylation and disrupting promoter-LCR interactions.

Targeted intragenic demethylation initiates chromatin rewiring for gene activation

CRISPR-DiR induces locus-specific demethylation and chromatin remodeling to reactivate the p16 gene.

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression

The paper identifies the DNA binding domain and sequence of SALL4, discovers its target genes in liver cancer cells, and reveals its mechanism of gene regulation.

Widespread interaction between ADAR1 and transcriptional byproducts

This study identifies ADAR1's interaction with transcriptional byproducts using integrated sequencing data, revealing its role in RNA processing and debris clearance.