RNA LEVER Mediates Long-Range Regulation of ε-globin by Keeping PRC2 in Check
Wei Wen Teo, Xinang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou, Chong Gao, Kim Vanuytsel, Sara S. Kumar, George J. Murphy, Henry He Yang, Li Chai, Daniel Geoffrey Tenen
The paper identifies LEVER RNA as a regulator of ε-globin expression by inhibiting PRC2-mediated H3K27 methylation and disrupting promoter-LCR interactions.
Communications Biology · Apr 11, 2022Peer-reviewedMolecular Biology