Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state
Martin Polák, Irena Selicharová, Matyáš Pinkas, María Soledad Garre Hernández, Benjamin Fabre, Marta Lubos, Lenka Žáková, Michał Grzybek, Ingmar B. Schäfer, Ünal Coskun, Jiřı́ Jiráček, Jiří Nováček
This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.
bioRxiv · Aug 5, 2025 · PreprintMolecular Biology