Author

Martin Polák

Central European Institute of Technology – Masaryk UniversityORCID 0009-0002-6572-9276Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Benjamin FabreiD· 1 shared Ingmar B. SchäferiD· 1 shared Irena SelicharováiD· 1 shared Jiří NováčekiD· 1 shared Jiřı́ JiráčekiD· 1 shared Lenka ŽákováiD· 1 shared María Soledad Garre HernándeziD· 1 shared Marta LubosiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Benjamin FabreORCID

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1 paper

Recent·Most cited

Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state

Martin Polák, Irena Selicharová, Matyáš Pinkas, María Soledad Garre Hernández, Benjamin Fabre, Marta Lubos, Lenka Žáková, Michał Grzybek, Ingmar B. Schäfer, Ünal Coskun, Jiřı́ Jiráček, Jiří Nováček

This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.

bioRxiv · Aug 5, 2025 · PreprintMolecular Biology