Author

Ünal Coskun

German Center for Diabetes ResearchORCID 0000-0003-4375-3144Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Michał GrzybekiD· 2 shared Triantafyllos ChavakisiD· 2 shared Aimée Bastidas-PonceiD· 1 shared Alessandra PalladiniiD· 1 shared Andreas DahliD· 1 shared Andres Soto· 1 shared Anika Aderhold· 1 shared Anupam N. SinhaiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Michał GrzybekORCID

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4 papers

Recent·Most cited

Antagonistic insulin mimetics lock the insulin receptor in an alternative apo-state

Martin Polák, Irena Selicharová, Matyáš Pinkas, María Soledad Garre Hernández, Benjamin Fabre, Marta Lubos, Lenka Žáková, Michał Grzybek, Ingmar B. Schäfer, Ünal Coskun, Jiřı́ Jiráček, Jiří Nováček

This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.

bioRxiv · Aug 5, 2025 · PreprintMolecular Biology

AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolism

Christine Mund, Anupam N. Sinha, Anika Aderhold, Ivona Mateska, Eman Hagag, Sofia Traikov, Bettina Gercken, Andres Soto, Jonathan Pollock, Lilli Arndt, Michele Wölk, Natalie Werner, Georgia Fodelianaki, Pallavi Subramanian, Kyoung‐Jin Chung, , Vasileia Ismini Alexaki

This study identifies AZIN2 as a regulator of adipocyte progenitor fate through polyamine metabolism, showing its protective role against obesity and metabolic dysfunction.

Metabolism · Aug 5, 2025Peer-reviewedCell Biology

Synaptotagmin 13 orchestrates pancreatic endocrine cell egression and islet morphogenesis

Mostafa Bakhti, Aimée Bastidas-Ponce, Sophie Tritschler, Oliver Czarnecki, Marta Tarquis-Medina, Eva Nedvedova, Jessica Jaki, Stefanie Julia Willmann, Katharina Scheibner, Perla Cota, Ciro Salinno, Karsten Boldt, Nicola Horn, Marius Ueffing, Ingo Burtscher, , Heiko Lickert

This study identifies Synaptotagmin 13 as a key regulator of endocrine cell egression and islet formation through its role in cell polarity and basement membrane remodeling.

Nature Communications · Aug 4, 2022Peer-reviewedDevelopmental Biology

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

Michal Grzybek, Alessandra Palladini, Vasileia I Alexaki, Michal A. Surma, Kai Simons, Triantafyllos Chavakis, Christian Klose, Ünal Coskun

This paper presents a validated shotgun lipidomics method for adipose tissue, revealing diet-related lipidomic differences in brown, gonadal, and inguinal subcutaneous fat from lean and obese mice.

bioRxiv · Nov 14, 2018Physiology