Jonathon A. Ditlev

The paper introduces a photocrosslinkable inhibitor, AZ, to selectively and spatiotemporally control Arp2/3 complex-dependent actin nucleation in live cells.

The paper derives a solubility product model for biomolecular phase boundaries, showing it accounts for variable stoichiometry and soluble oligomers, revealing curvature and re-entrant behavior in phase boundaries.

This study shows that protein interactions, calcium, phosphorylation, and cholesterol regulate CFTR cluster formation on membranes through multivalent interactions and phase separation.

The paper shows that disease-linked shank2 mutations alter condensate physical properties and composition, leading to aberrant RNA translation.

The paper measures the solubility product in a model condensate to predict phase separation, finding that small oligomers and homotypic interactions influence the threshold.