Author

Matt Lechner

University College LondonORCID 0000-0002-7123-0773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Federico ComoglioiD· 2 shared Kenny VuiD· 2 shared Marco NotaroiD· 2 shared Nyall R. LondoniD· 2 shared Ramya ViswanathaniD· 2 shared Sreenivasulu Gunti· 2 shared Aaron M. UdageriD· 1 shared Andrew P. LaneiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenomics

Federico ComoglioORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation

Tolani F. Olonisakin, Fernando Tadeu Zamunér, Kenny Vu, Sreenivasulu Gunti, Y M Ding, Yue Hou, Xinping Yang, Ramya Viswanathan, Angel Huynh, Federico Comoglio, Marco Notaro, Christopher Cherry, Michael Patatanian, Nathan W. Wong, Timothy R. DeKlotz, , Nyall R. London

This study identifies molecular and immune mechanisms driving malignant transformation from inverted papilloma to sinonasal squamous cell carcinoma using multi-omics analyses.

bioRxiv · Jun 4, 2026 · PreprintGenomics

In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis

Kenny Vu, Sreenivasulu Gunti, Ramya Viswanathan, Anjali Nandal, Riley M. Larkin, Sung‐Woo Cho, Jonathan Zou, Shivani Ramolia, Austin T.K. Hoke, Siani Barbosa, Gary L. Gallia, Lisa M. Rooper, Charalampos S. Floudas, Hui Wen Cheng, Christine N. Miller, , Nyall R. London

This study identifies NF1/RASA1/TP53 co-mutations and MEK signaling as key drivers of sinonasal tumorigenesis through in vivo CRISPR screening and drug response testing.

bioRxiv · May 19, 2025 · PreprintCancer Biology