Author

Minhee Lee

Columbia UniversityORCID 0000-0002-7141-7351Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Neel H. ShahiD· 4 shared Andrew C. JohnsiD· 2 shared Anne E. van VlimmereniD· 2 shared David C. CabaneroiD· 1 shared Devon A. SemoyiD· 1 shared José L. McFaline‐FigueroaiD· 1 shared Marko JovanovićiD· 1 shared Ross M. GiglioiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

Neel H. ShahORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Substrate-derived peptides for selective covalent inhibition of protein tyrosine kinases

Minhee Lee, Andrew C. Johns, Zijing Wang, Devon A. Semoy, Neel H. Shah

This paper develops a modular strategy to design selective covalent inhibitors of protein tyrosine kinases using substrate-derived peptides, demonstrating selectivity for specific kinases and mutants.

ACS Chemical Biology · Aug 24, 2026Peer-reviewedBiochemistry

Identification of substrates of the protein tyrosine phosphatase PTP1B using in situ site-specific photo-crosslinking

Andrew C. Johns, Yethmie S Goonatilleke, David C. Cabanero, Yanzhe Ma, Minhee Lee, Anne E. van Vlimmeren, Marko Jovanović, Neel H. Shah

This paper identifies PTP1B substrates using in situ photo-crosslinking, revealing new substrates and interactions, including EGF receptor binding.

bioRxiv · Jul 10, 2026 · PreprintBiochemistry

Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants

Anne E. van Vlimmeren, Ross M. Giglio, Ziyuan Jiang, Minhee Lee, José L. McFaline‐Figueroa, Neel H. Shah

This study uses single-cell transcriptomics to analyze how diverse SHP2 variants affect gene expression and cellular phenotypes in relation to disease.

Science Advances · May 22, 2026Peer-reviewedMolecular Biology

Profiling tyrosine kinase substrate recognition using bacterial peptide display and deep sequencing

Minhee Lee, Neel H. Shah

This paper introduces a method combining bacterial peptide display and deep sequencing to profile tyrosine kinase substrate recognition, showing strong correlation with enzyme kinetics and revealing new substrate specificity insights.

bioRxiv · Dec 30, 2025 · PreprintBiochemistry