Andrew C. Johns

This paper develops a modular strategy to design selective covalent inhibitors of protein tyrosine kinases using substrate-derived peptides, demonstrating selectivity for specific kinases and mutants.

This paper identifies PTP1B substrates using in situ photo-crosslinking, revealing new substrates and interactions, including EGF receptor binding.

This paper shows that Grb2 binding to PTP1B allosterically enhances its catalytic activity through structural changes, revealing a new regulatory mechanism for PTP1B in cell signaling.