Yanzhe Ma

Coordinated RNA- and protein-templated synthesis ofdouble-stranded DNA by a dual reverse transcriptase immune system

The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.

The UPR drives gametogenesis via an unexpected response, coordinating translation and ER structure

The paper shows that the endogenous UPR in budding yeast is essential for gametogenesis, coordinating translation and ER structure through a distinct mechanism from exogenous UPR activation.

Identification of substrates of the protein tyrosine phosphatase PTP1B using in situ site-specific photo-crosslinking

This paper identifies PTP1B substrates using in situ photo-crosslinking, revealing new substrates and interactions, including EGF receptor binding.

Blm10 scaffolds 14-3-3 adaptors to the proteasome, and maintains cellular proteostatic balance and gamete quality

This study identifies Blm10 as a proteasome-associated protein that modulates proteasome activity and maintains proteostasis and gamete quality in yeast.

Antiviral reverse transcriptases reveal the evolutionary origin of telomerase

The paper identifies DRT10, an antiviral reverse transcriptase, and shows its structural and mechanistic similarities to telomerase, suggesting a bacterial origin for telomerase.

Protein-primed DNA homopolymer synthesis by an antiviral reverse transcriptase

The paper reveals a novel DNA homopolymer synthesis mechanism by DRT9, triggered by viral infection to induce abortive infection and population-level immunity.

Large-scale map of RNA binding protein interactomes across the mRNA life-cycle

The paper constructs an RNA-aware RBP-centric PPI map across the mRNA life-cycle, revealing 20,359 novel interactions and showing 73% are RNA-dependent.

A Multiplexed SEC-MS Approach to Systematically Study the Interplay Between Protein Assembly-States and Phosphorylation Events

The paper introduces SEC-MX, a method to simultaneously study protein assembly-states and phosphorylation events, and demonstrates its application in HEK293 and HCT116 cells.