Stephanie M. Hughes

Transcription factor-mediated generation of dopaminergic neurons from human iPSCs: a comparison of methods

This study compares three protocols for generating dopaminergic neurons from human iPSCs using transcription factors, finding that combining transcription factors with small molecules yields over 80% dopaminergic neurons.

Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures

This study examines the effects of chronic CBD in a mouse model of neuroinflammation, neurodegeneration, and seizures, finding reduced astrocytosis and microgliosis but no impact on seizures or neuron survival.

Deficiency of the lysosomal protein CLN5 alters lysosomal function and movement

This study investigates lysosomal dysfunction in CLN5-deficient human neurons, finding impaired lysosomal acidity, enzyme activity, and movement.

Anterior thalamic nuclei neurons sustain memory

This study shows that optogenetic stimulation of anterior thalamic nuclei neurons improves spatial working memory in rats with MTT lesions by enhancing rhythmic activity and gene expression.