Sadhan Das

PAD4-mediated histone citrullination contributes to enhanced NETosis in type 2 diabetes but not in type 1 diabetes

The paper identifies distinct mechanisms of enhanced NETosis in type 1 and type 2 diabetes, showing PAD4-independent pathways in T1D and PAD4-dependent pathways in T2D.

Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control

This study uses single-cell multi-omics to show that diabetic mice show persistent aortic smooth muscle cell dysfunction and phenotypic changes despite glycemic control, with partial reversal by dapagliflozin.

The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18

This study identifies TFIIIC220 as a lysine acetyltransferase that acetylates histone H3K18, highlighting its role in maintaining acetylation homeostasis.