Yingjun Luo

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

This study uses single-cell multi-omics to show that diabetic mice show persistent aortic smooth muscle cell dysfunction and phenotypic changes despite glycemic control, with partial reversal by dapagliflozin.

This study shows that inhibiting endothelial AGO1 reduces vascular inflammation and atherosclerosis by blocking its non-canonical nuclear role in promoting NF-κB-driven inflammation.

The paper identifies mitochondrial RNAs (mtRNAs) as chromatin-associated RNAs (caRNAs) that regulate nuclear transcription in response to stress and disease.

The paper investigates how RNA-chromatin interactions change in endothelial cells under high-glucose and TNF treatment, showing their role in inflammation and endothelial dysfunction.