Author

Karen M. Mann

Moffitt Cancer CenterORCID 0000-0002-7161-4523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Agnieszka Katarzyna WitkiewicziD· 1 shared Alcida KarziD· 1 shared Alexander Hall HickmaniD· 1 shared Benjamin D. GreenbaumiD· 1 shared Danny IncarnatoiD· 1 shared Dave Keng Boon Wee· 1 shared David J. MulhollandiD· 1 shared Diana H. P. LowiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Agnieszka Katarzyna WitkiewiczORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma

Katherine J. Crawford, Kennedy S. Humphrey, Eduardo Cortes Gomez, Jianxin Wang, Vishnu Muthuraj Kumarasamy, Yin Wan, Mark D. Long, Michael E. Feigin, Agnieszka Katarzyna Witkiewicz, Karen M. Mann, Erik S. Knudsen, Ethan V. Abel

This study identifies HNF1A as an oncogenic driver of PDAC metastasis through upregulation of FGFR4 and shows that FGFR4 inhibition reduces metastasis in vitro and in vivo.

Molecular Cancer · Jul 29, 2025Peer-reviewedCancer Biology

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain prostate cancer cell fitness

Jessica Ho, Federico Di Tullio, Megan Catherine Schwarz, Diana H. P. Low, Danny Incarnato, Florence P. H. Gay, Tommaso Tabaglio, Jingxian Zhang, Heike Wollmann, Leilei Chen, Ömer An, Tim Hon Man Chan, Alexander Hall Hickman, Simin Zheng, Vladimir Roudko, , Ernesto Guccione

This study identifies HNRNPM as a splicing factor critical for prostate cancer cell growth by regulating splicing fidelity and circRNA biogenesis, suggesting it as a therapeutic target.

eLife · Jun 2, 2021Peer-reviewedGenomics