Taryn D. Treger

Extensive and differential platinum chemotherapy mutagenesis in children

This study uses duplex sequencing to analyze platinum chemotherapy-induced mutagenesis in pediatric tissues, revealing extensive mutational signatures and tissue-specific effects.

Single cell transcriptional evolution of myeloid leukaemia of Down syndrome

The paper examines the transcriptional evolution of myeloid leukaemia in Down syndrome by analyzing single-cell RNA sequencing data from patient samples and fetal tissues.

Cancer-independent, second somatic NF1 mutation of normal tissues in neurofibromatosis type 1

The paper identifies second somatic NF1 mutations in normal tissues of neurofibromatosis type 1 patients through whole genome and exome sequencing, showing positive selection of truncating mutations in these tissues.

Subtype-specific Patterns of Evolution and Clinically Relevant Genomic Instability in Wilms Tumour

This study analyzes the evolutionary patterns and genomic instability in Wilms tumors, identifying subtype-specific evolutionary sequences and proposing CNA diversity as a prognostic biomarker.

Single cell mRNA signals reveal a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

The paper identifies a distinct developmental state in KMT2A-rearranged infant B-cell acute lymphoblastic leukemia using single-cell transcriptome analysis.