Author

Rebecca Thomas

Great Ormond Street Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CITE-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Jack Luke BartramiD· 4 shared Ágnes OszláncziiD· 1 shared Alice GiustacchiniiD· 1 shared Alona SosinskyiD· 1 shared Anastasios KaradimitrisiD· 1 shared Angus HodderiD· 1 shared Anindita RoyiD· 1 shared Anna WengeriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCancer Biology

Jack Luke BartramORCID

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4 papers

Recent·Most cited

Recurrent leukaemia stem cell states define the antigenic landscape of paediatric Acute Myeloid Leukaemia

Sina Kanannejad, Macarena Oporto Espuelas, Claudia D’Oria, Filippo Martignano, Ilaria Marina Michelozzi, Soumick Chatterjee, Edoardo Giacopuzzi, Eduardo Gomez Castaneda, Aurora Casiraghi, Theodoros Xenakis, George T. Hall, Efstratios Kirtsios, Cecilia Reyneri, Hannah L. Macpherson, Jack Luke Bartram, , Alice Giustacchini

This study identifies three leukaemia stem cell subtypes in paediatric AML and shows that combining CLEC12A and CD84 targets all subtypes while sparing healthy cells.

bioRxiv · Oct 23, 2026 · PreprintCancer Biology

Single cell transcriptional evolution of myeloid leukaemia of Down syndrome

Mi K. Trinh, K Schuschel, Hasan Issa, Rebecca Thomas, Conor Parks, Ágnes Oszlánczi, Toochi Ogbonnah, Di Zhou, Lira Mamanova, Elena Prigmore, Emilia Robertson, Angus Hodder, Anna Wenger, Nathaniel D. Anderson, Holly J. Whitfield, , Sam Behjati

The paper examines the transcriptional evolution of myeloid leukaemia in Down syndrome by analyzing single-cell RNA sequencing data from patient samples and fetal tissues.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease

Hongwei Ren, Natalina Elliott, Bryan Lye, Mohammad Umer Sharif Shohan, Joe W. Cross, Lucy May Field, Kanagaraju Ponnusamy, Siobhan Rice, Thomas Jackson, Ilia Leontari, Nouhad El Ouazzani, Rebecca Thomas, Sarah Inglott, Jack Luke Bartram, Owen Patrick Smith, , Anastasios Karadimitris

This paper develops bi-specific CAR-iNKT cells targeting CD19 and CD133 for KMT2A-rearranged leukemia, showing superior efficacy over CAR-T in eradicating leptomeningeal disease and inducing remission.

bioRxiv · Jan 22, 2025 · PreprintCancer Biology

Clinical application of tumour-in-normal contamination assessment from whole genome sequencing

Jonathan Mitchell, Salvatore Milite, Jack Luke Bartram, Susan Walker, Nadezda V. Volkova, Olena Yavorska, Magdalena Zarowiecki, Jane Chalker, Rebecca Thomas, Luca Vago, Alona Sosinsky, Giulio Caravagna

The paper develops a tool to assess tumour contamination in normal samples using whole-genome sequencing data, finding contamination in various cancer types and highlighting risks to variant calling.

Nature Communications · Jan 18, 2024Peer-reviewedBioinformatics