Author

Kathy Pritchard‐Jones

Great Ormond Street HospitalORCID 0000-0002-2384-9475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Abdelkader Essafi· 1 shared Alex von KriegsheimiD· 1 shared Borbála MifsudiD· 1 shared Debasis Mohapatra· 1 shared Gaganjit Kaur MadhaniD· 1 shared George D. CresswelliD· 1 shared Giulia Petrovich· 1 shared Gordan M. VujaniciD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abdelkader Essafi

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2 papers

Recent·Most cited

Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme

Sourav Dey, Joan Slight, Stuart Aitken, Iwin Joseph, Utkarsh Bhore, Alex von Kriegsheim, Giulia Petrovich, Jocelyn Charlton, Viktoriya G. Stancheva, Debasis Mohapatra, Abdelkader Essafi, Kathy Pritchard‐Jones, Nicholas Dixon Hastie, Ruthrothaselvi Bharathavikru

The paper shows WT1 and DDX5 regulate the let7/Igf1r axis in kidney mesenchyme, linking WT1 mutations to Wilms Tumour through microRNA and IGF signalling pathways.

bioRxiv · Jan 5, 2025 · PreprintCancer Biology

Subtype-specific Patterns of Evolution and Clinically Relevant Genomic Instability in Wilms Tumour

George D. Cresswell, Tasnim Chagtai, Reem Al‐Saadi, Taryn D. Treger, Gaganjit Kaur Madhan, Borbála Mifsud, Gordan M. Vujanic, Richard Dafydd Williams, Nicholas M. Luscombe, Kathy Pritchard‐Jones, William Mifsud

This study analyzes the evolutionary patterns and genomic instability in Wilms tumors, identifying subtype-specific evolutionary sequences and proposing CNA diversity as a prognostic biomarker.

bioRxiv · Sep 4, 2024 · PreprintCancer Biology