Author

Karin C. M. Straathof

Great Ormond Street HospitalORCID 0000-0001-9673-8568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Sam BehjatiiD· 5 shared Nathaniel D. AndersoniD· 4 shared Elena PrigmoreiD· 3 shared Matthew D. YoungiD· 3 shared Mi K. TrinhiD· 3 shared Taryn D. TregeriD· 3 shared Alice PiapiiD· 2 shared Angus HodderiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersCancer Biology

Sam BehjatiORCID

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Author profile →

5 papers

Recent·Most cited

Embryonic origin of cancer in newborn twins

Barbara Walkowiak, Sadie Baskind, Manàs Dave, Pooja Balasubramanian, Nathaniel D. Anderson, Jonathan Kennedy, Thomas R. W. Oliver, Rohan Verma, Sarita Depani, Simon Hannam, Tom A. Watson, Dyanne Rampling, Karin C. M. Straathof, Liina Palm, John Ciaran Hutchinson, , Sam Behjati

The paper uses whole genome sequencing to study cancer spread between monozygotic twins, revealing asymmetrical embryonic lineage contributions to the placenta and twins.

Nature Communications · Oct 6, 2026Peer-reviewedCancer Biology

Extensive and differential platinum chemotherapy mutagenesis in children

Anna Wenger, Henry Lee-Six, Manàs Dave, Mehdi Layeghifard, Andrew R. J. Lawson, Federico Abascal, Pantelis A. Nicola, Taryn D. Treger, Toochi Ogbonnah, Conor Parks, Thomas R. W. Oliver, Jonathan Kennedy, Angus Hodder, Nathaniel D. Anderson, Felipe Luz Torres Silva, , Sam Behjati

This study uses duplex sequencing to analyze platinum chemotherapy-induced mutagenesis in pediatric tissues, revealing extensive mutational signatures and tissue-specific effects.

bioRxiv · Oct 12, 2025 · PreprintCancer Biology

Single cell transcriptional evolution of myeloid leukaemia of Down syndrome

Mi K. Trinh, K Schuschel, Hasan Issa, Rebecca Thomas, Conor Parks, Ágnes Oszlánczi, Toochi Ogbonnah, Di Zhou, Lira Mamanova, Elena Prigmore, Emilia Robertson, Angus Hodder, Anna Wenger, Nathaniel D. Anderson, Holly J. Whitfield, , Sam Behjati

The paper examines the transcriptional evolution of myeloid leukaemia in Down syndrome by analyzing single-cell RNA sequencing data from patient samples and fetal tissues.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Precise identification of cancer cells from allelic imbalances in single cell transcriptomes

Mi K. Trinh, Clarissa N. Pacyna, Gerda Kildisiute, Christine Thevanesan, Alice Piapi, Kirsty Ambridge, Nathaniel D. Anderson, Eleonora Khabirova, Elena Prigmore, Karin C. M. Straathof, Sam Behjati, Matthew D. Young

The paper identifies cancer cells from single cell transcriptomes by using allelic imbalances to accurately separate cancer from non-cancer cells.

Communications Biology · Sep 7, 2022Peer-reviewedGenomics

Single cell mRNA signals reveal a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

Eleonora Khabirova, Laura Jardine, Tim H. H. Coorens, Simone Webb, Taryn D. Treger, Justin Engelbert, Tarryn Porter, Elena Prigmore, Grace Collord, Alice Piapi, Sarah Amalia Teichmann, Sarah Inglott, Owen Williams, Olaf T Heidenreich, Matthew D. Young, , Sam Behjati

The paper identifies a distinct developmental state in KMT2A-rearranged infant B-cell acute lymphoblastic leukemia using single-cell transcriptome analysis.

Nature Medicine · Mar 14, 2022Peer-reviewedGenomics