Isabel Nadine Goronzy

SPIDR: a highly multiplexed method for mapping RNA-protein interactions uncovers a potential mechanism for selective translational suppression upon cellular stress

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

High-resolution spatial multi-omics reveals cell-type specific nuclear compartments

This study uses high-resolution spatial multi-omics to analyze subnuclear compartments in single cells, revealing cell-type specific chromatin structures and their genomic associations.

ChIP-DIP: A multiplexed method for mapping hundreds of proteins to DNA uncovers diverse regulatory elements controlling gene expression

ChIP-DIP enables simultaneous mapping of hundreds of regulatory proteins to DNA, revealing diverse regulatory elements and their functional activity.

3D genome organization around nuclear speckles drives mRNA splicing efficiency

The paper shows that gene proximity to nuclear speckles increases spliceosome binding and co-transcriptional splicing efficiency, highlighting the role of 3D genome organization in mRNA splicing.

RNA promotes the formation of spatial compartments in the nucleus

The paper develops RD-SPRITE to map RNA-DNA and RNA-RNA interactions in 3D nuclear structures, revealing RNA's role in forming compartments that regulate nuclear functions.