This paper introduces LagTag, a method to recover both earlier and endpoint chromatin states in mammalian cells, and applies it to study dynamic chromatin transitions during stem cell differentiation.

Cell Systems · Sep 1, 2026Peer-reviewedGenomics

SPIDR: a highly multiplexed method for mapping RNA-protein interactions uncovers a potential mechanism for selective translational suppression upon cellular stress

Erica Wolin, Jimmy K. Guo, Mario R. Blanco, Isabel Nadine Goronzy, Darvesh Gorhe, Wenzhao Dong, Andrew A. Perez, Abdurrahman Keskin, Elizabeth Valenzuela, Ahmed A. Abdou, Carl R. Urbinati, Ross T. Kaufhold, H. Tomas Rube, Jailson Brito Querido, Mitchell Guttman, Marko Jovanović

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

Cell · Jul 22, 2025Peer-reviewedSystems Biology

ChIP-DIP: A multiplexed method for mapping hundreds of proteins to DNA uncovers diverse regulatory elements controlling gene expression

Andrew A. Perez, Isabel Nadine Goronzy, Mario R. Blanco, Benjamin T. Yeh, Jimmy K. Guo, Carolina S. Lopes, Olivia Ettlin, Alex Burr, Mitchell Guttman

ChIP-DIP enables simultaneous mapping of hundreds of regulatory proteins to DNA, revealing diverse regulatory elements and their functional activity.

Nature Genetics · Nov 25, 2024Peer-reviewedGenomics