Robert B. Russell

Phylogeny and gene function integration uncovers multiple convergences in multicellular and terrestrial transitions

The paper integrates phylogenomics and functional annotations to trace gene function evolution across species, revealing convergent adaptations in multicellular and terrestrial transitions.

PROTEORIZER: A holistic approach to untangle functional consequences of variants of unknown significance.

Proteorizer contextualizes variants of unknown significance by integrating functional knowledge from related proteins and their 3D structures to predict functional consequences.

De-suppression of mesenchymal cell identities and variable phenotypic outcomes associated with knockout of Bbs1.

The paper investigates the role of BBS1 in suppressing mesenchymal cell identities in epithelial cells, showing clonal variability and dysregulation of EMT genes across tissues.

CiliaCarta: An Integrated And Validated Compendium Of Ciliary Genes

The paper identifies 285 candidate ciliary genes using integrated genomic, proteomic, and transcriptomic data, validated by experimental evidence and creating a resource for ciliopathy research.