This study examines how specific BBS1 mutations affect BBSome assembly and function in ciliary trafficking, revealing distinct defects linked to different BBS1 variants.

Cell Communication and Signaling · Jun 19, 2026Peer-reviewedCell Biology

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade

Tommy J Sroka, Lea K. Sanwald, Avishek Prasai, Josefine Hoeren, Karina von der Malsburg, Valerie Chaumet, Per Haberkant, Kerstin Feistel, David U. Mick

The paper introduces iAPEX, an improved APEX-based proximity labeling method for live-cell proteomics, and applies it to study primary cilia in Xenopus laevis, identifying new ciliary proteins and validating existing ones.

bioRxiv · Jan 10, 2025 · PreprintBiochemistry

De-suppression of mesenchymal cell identities and variable phenotypic outcomes associated with knockout of Bbs1.

Grace Freke, Tiago Martins, Rosalind Jane Davies, Tina Beyer, Marian Seda, Emma Peskett, Naila Haq, Avishek Prasai, Georg Otto, Jeshmi Jeyabalan, Víctor Hernández-Hernández, Gaurav D. Diwan, Robert B. Russell, Marius Ueffing, Martina Huranová, , Dagan Jenkins

The paper investigates the role of BBS1 in suppressing mesenchymal cell identities in epithelial cells, showing clonal variability and dysregulation of EMT genes across tissues.

Cells · Nov 20, 2023Peer-reviewedGenetics

Altered hematopoietic system and self-tolerance in Bardet-Biedl Syndrome

Oksana Tsyklauri, Veronika Niederlová, Elizabeth L. Forsythe, Avishek Prasai, Ales Drobek, Petr Kašpárek, Kathryn Sparks, Zdeněk Trachtulec, Jan Procházka, Radislav Sedláček, Philip L. Beales, Martina Huranová, Ondřej Štěpánek

This study investigates immune and hematopoietic system alterations in Bardet-Biedl Syndrome patients and a mouse model, finding increased autoimmune disease incidence, elevated white blood cell counts, and B cell abnormalities.

EMBO Reports · Jan 11, 2021Peer-reviewedGenetics