Claudia Álvarez-Carreño

Deep shifts in Evolutionary Rate Trajectories of Ancient Bacterial Genes

The paper reconstructs evolutionary rate trajectories of 528 genes from the Last Bacterial Common Ancestor across 2.1 billion years, identifying four clusters with distinct patterns linked to gene function and environmental changes.

TEDLH: Domain HMMs for sensitive detection of remote homologues

The paper introduces TEDLH, a library of domain HMMs derived from TED annotations, enabling sensitive detection of remote homologues and expanding coverage of sequence space and CATH superfamily diversity.

BEAN and HABAS: Polyphyletic insertions in RNAP that point to deep-time evolutionary divergence of bacteria

The paper identifies BEAN and HABAS domains in bacterial RNA polymerase subunits, showing their evolutionary divergence and phylogenetic distribution.

AARS Online: a collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

Translation in a Box: Orthogonal Evolution in the Saccharomyces cerevisiae Mitochondrion

This paper demonstrates the directed evolution of the Saccharomyces cerevisiae mitochondrial translation system as an orthogonal system to the cytosolic TS, revealing functional dependencies and enabling translation engineering.