Luke Child Dabin

SAHA provides a statistical framework for rapid cell type annotation by transferring labels from reference datasets to query datasets without integration.

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

This study uses single-nucleus RNA sequencing to show that tau ablation alters brain cell programs in health and restores function in vascular amyloid disease.

This study compares three nuclei isolation methods for brain snRNA-seq, finding protocol-dependent differences in cell type proportions, transcriptional homogeneity, and RNA contamination levels.

This study develops a robust snRNA-seq method to analyze depot-specific adipose tissue remodeling during obesity, identifying distinct adipocyte subpopulations and their functional trajectories.

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.