Arnar Breevoort

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD

The paper identifies molecular subtypes of neurons in the frontoinsular cortex and links specific gene expression patterns to neuronal vulnerability in FTD.

Fate plasticity of interneuron specification

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex.

The paper shows that deletion of the Pcdhγc4 isoform increases cortical interneuron cell death, while viral expression rescues it, highlighting its critical role in regulating survival during programmed cell death.