Jaeyong Choi

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

The paper develops a bioinformatics pipeline to reduce misalignment errors in mixed human and mouse single-cell RNA sequencing data, improving clustering and accuracy compared to existing methods.

This study shows that deleting STAT3 in Purkinje cells alters synaptic plasticity and enhances long-term fear memory.