Yang Gao

This study presents dynamic structures of MCM8/9 with DNA, HROB, and ATP analogs to elucidate the mechanism of MCM8/9 DNA unwinding and activation by HROB.

This paper determines the structure of HELLS in its autoinhibitory state and shows how CDCA7 and DNA activate it.

The paper uses single-molecule FRET to study exonuclease activity in T4 phage MR complexes, revealing two distinct activity states and their regulation by the Mre11 dimer interface.

The paper challenges the validation of ZYS-1 as an ADAR1 inhibitor, showing it lacks inhibitory activity in validated assays.

This study characterizes ADAR1's RNA editing mechanism through biochemical profiling and structural analysis, revealing sequence and duplex length dependence, disease mutation impacts, and the role of RNA-binding domain 3.

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

This study uses time-resolved crystallography to investigate the catalytic mechanism of His-Me family I-PpoI nuclease, revealing the role of a single divalent metal ion and histidine in DNA hydrolysis.